Despite the fact that the mechanism of action of honey on oral mucositis is not well established, it may be due to the analgesic [ 80], antimicrobial [ 81], and wound-healing [ 82] properties that have been attributed to this food. In addition, qualities, such as high viscosity, high osmolarity, and low pH level of honey enhance its bacterial and fungal inhibitory activity [ 80]. On the one hand, since honey contains a characteristic sweetness [ 80] as well as ascorbic, citric, and malic acids [ 35], it increases salivation, and thus promotes repair and healing of the oral mucosa. On the other hand, weight loss is very common in cancer patients and has negative effects, such as increased risk of infection and reduced quality of life, treatment responses, and survival [ 83]. The positive effect of honey on body weight in cancer patients may be due to its positive effects on mucositis, as this results in increased oral food intake [ 84]. The positive effect of honey against neutropenia could be associated with its antioxidant [ 40], antimicrobial, and immunomodulatory [ 41] properties. Another hypothesis is that honey could increase levels of granulocyte colony stimulating factor (G-CSF) [ 41], which induces neutrophil production [ 85] by increasing TNF-α and IL-1. The evidence seems to indicate that honey is quite beneficial for cancer patients, although more standardized and longer-term studies are needed to confirm these effects.

LifeMel is not artificially treated in any way and no ingredients are added after extraction from the hive. LifeMel has a distinctive, pleasant aroma and flavour.Since I began taking the special honey, I have witnessed a significant increase in white blood-cells, neutrophils and iron; I highly recommend LifeMel honey. -Ronit, Haifa Mixture of four types of clover honey obtained from Golden Heritage Foods, Smitty Bee Honey, Millers Honey Company, and Marshall’s Farm Natural Honey Life Mel was featured in CAM Lifestyle - "Research published in in Medical Oncology shows that LifeMel helps maintain a better white blood cell count during chemotherapy and can boost immunity before, during and after chemotherapy." One author, Prof Eitan Friedman, head of the Susanne Levy Gertner Oncogenetics Unit at Chaim Sheba Medical Centre in Israel, seems irritated that the company uses the study and his name to promote the product. The main criteria of PICO (Population, Intervention, Comparison, Outcome) were followed to frame and answer the clinical-related question. In this regard, the population included humans (healthy subjects, subjects who are overweight or obese, diabetes, cancer, wounds, infections, and inflammation), the intervention was treatment with different types of honey, oral or topical, without combining it with other substances, and the comparison was made between honey and other sugar sweeteners. The outcome was cardiovascular, anticancer, antidiabetic, antimicrobial and antiviral, anti-obesity and antioxidant effects.

Plasma concentrations of C-peptide effectively reflect endogenous insulin secretion; therefore, it is considered a good marker of insulin secretion. Increases in C-peptide levels following honey consumption in both healthy and diabetic subjects demonstrate that honey may stimulate both healthy and diseased pancreatic beta cells. It is thought that due to its anti-inflammatory [ 62], antioxidant [ 75], antiviral and probiotic [ 76] properties, honey may contribute to the healing of diseased beta cells [ 25]. On the other hand, Panero et al. [ 77] observed that higher levels of C-peptide in type I diabetic patients confer a statistically significant protective effect against the development of microvascular complications. Furthermore, due to the Lactobacillus and Bifidobacterium involved in its production, honey is considered a fermented and, consequently, probiotic product, which could reduce inflammation and intestinal permeability, and change the composition of the intestinal flora, these factors being implicated in the pathogenesis of type I diabetes mellitus [ 78]. Moreover, the antidiabetic and hypoglycemic capacity of honey can be attributed to its antioxidant ability (thanks to its phenolic compound content), as the pathogenesis of diabetes mellitus appears to be closely associated with the presence of oxidative stress and ROS [ 7].

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LifeMel Honey uses nectar derived from therapeutic herbs including Siberian Ginseng, Echinacea and Uncaria Tomentosa, combined with a selection of natural ingredients including iron, protein and vitamins. My life's research and interest in the field of apitherapy has focused on this very aspect of honey, and I have sought to uncover the ways in which honey can be harnessed and manipulated to create supplements that can be tailored to target specific ailments and conditions.